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While many people obtain B12 through their diet, certain factors such as a lack of animal products or impaired absorption can lead to B12 deficiency, making B12 shots an effective method to ensure adequate levels of this crucial nutrient

Possible adverse effects of B12 treatment include injection-site reactions (with intramuscular preparations), and rarely hypersensitivity reactions including anaphylaxis

Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

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