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322,323 In two ACG position papers (2018 and 2021) on the management of IBS, loperamide is not recommended as a first-line therapy due to the limited trials and small number of patients included, as well as its inability to improve global IBS symptoms
65,78,79,80,81,82,83,84,85,86 Thus, at present, non-proliferative and proliferative astrocyte reactivity represent two broad categories that can be readily differentiated and are associated with diverse molecular and functional differences
Lee YJ, Javdan B, Cowan A, Smith K
It highlights its impact on oxidative stress, insulin signaling, and nutrient processing, while clarifying that it does not directly cause weight loss
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