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[9] In mammals, some GABAergic neurons, such as chandelier cells, are also able to excite their glutamatergic counterparts

Navolanic PM, Steelman LS, Leslie NR, Coffer PJ, Konopleva M, Hu W, Andreeff M , Blagosklonny MV, McMahon M, McCubrey JA

Most human study data does start on a lower dose of 100 to 200 milligrams of NMN, slowly working up to 500 milligrams, according to Jillian Robillard, MS, RD, LDN