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The dcolletage (chest area) responds well to copper peptides but may need lower concentrations than the face
specifically, mice inheriting a maternal targeted deletion of H19 show overexpression of IGF-2 [30]
Applied twice daily using 0.5ml per application, this provides 20mg per day of topical peptide (though actual absorption is much lower due to skin penetration limits)
The weight change at one year post-discontinuation was small, but depended heavily on the individual and may partly reflect the fact that many patients resumed or transitioned to other weight-management therapies rather than remaining untreated
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