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Clin Endocrinol (Oxf) 51:787792 Backeljauw PF, Underwood LE (1996) Prolonged treatment with recombinant insulin-like growth factor-1 in children with growth hormone insensitivity syndrome a clinical research center study
Once the fat cells are destroyed, it is permanent and they dont come back (if you dont follow the aftercare, you can put weight back on in the same area again)
More research is needed to establish its safety and effectiveness
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