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Chronic inhibition may theoretically disrupt: S-adenosylmethionine (SAMe) balance Homocysteine metabolism Epigenetic regulation Long-term alteration of methylation pathways may carry systemic consequences that are not yet understood, including potential impacts on cardiovascular and neurological health
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Vitamin B12-producing bacteria colonize the large bowel, but humans do not have the ability to absorb bacterial vitamin B12 from their large intestine
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