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In clinical studies, liraglutide and semaglutide both led to an average 0.3-point drop in A1c in prediabetic participants (after 56 weeks for liraglutide 5 and 68 weeks for semaglutide 6 )a small but meaningful shift for people whose blood sugar is creeping upward toward the diabetes threshold
By simultaneously activating GLP-1 pathways and amylin-calcitonin pathways, the combination produces appetite suppression and metabolic benefits that substantially exceed what either agent achieves alone
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