In the brain, the highest densities of GLP-1R are found in the nucleus of the solitary tract, posterior area, interpeduncular nucleus, posterior dorsal nucleus, ventral tegmental area, hypothalamic nuclei, thalamic nuclei, nucleus accumbens, and the lateral septum [5]
[END CALLOUT BOX] GLP2 Pharmacokinetics & Metabolism Absorption & Distribution Following subcutaneous administration, GLP2 exhibits favorable pharmacokinetic properties enabling once-weekly dosing: Mean absolute bioavailability of approximately 80% after subcutaneous injection Time to maximum plasma concentration (Tmax) ranges from 8 to 72 hours Steady-state plasma concentrations achieved after 4 weeks of once-weekly dosing Mean steady-state volume of distribution approximately 10.3 L, indicating limited tissue distribution The high plasma protein binding to albumin (99%) results from the C20 fatty diacid modification, which provides prolonged systemic exposure and enables sustained therapeutic effects between weekly doses
Semaglutide and tirzepatide are only approved for the treatment of certain conditions: obesity and overweight, type 2 diabetes, sleep apnea, and cardiovascular disease
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