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Simultaneously, it increased the activities of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR) and ascorbate peroxidase (APX)
It is important to note that DPP-4 inhibitors should not be used in combination with GLP-1 receptor agonists, as both drug classes act on the same incretin pathway and concurrent use is not supported by evidence or current guidance
These outcomes can be attributed to tirzepatides dual action , which targets both appetite suppression and insulin sensitivity
doi: 10.1016/j.phrs.2024.107187 128
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