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Elevated inflammatory markers in OA may trigger ferroptosis [24], hence perpetuating a detrimental cycle that intensifies joint inflammation and cartilage degradation [25]
Knowing these risk factors can help patients and healthcare providers better manage and anticipate this side effect
In addition, long-term leptin replacement therapy improves glycaemic control, insulin sensitivity and plasma triglycerides in patients with severe insulin resistance due to lipodystrophy
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