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It activates: GLP-1 , just like semaglutide GIP (glucose-dependent insulinotropic polypeptide) , a second hormone involved in appetite, insulin regulation, and fullness Because tirzepatide acts on two hormonal pathways, many patients experience: Stronger appetite control More stable blood sugar Greater total weight loss Better control over cravings Think of tirzepatide as a double-pathway medication that supports weight loss from multiple angles
While animal studies were encouraging and showed promising weight loss results, human trials were inconsistent
The scientific consensus had not changed since the 1970s
