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For example, a report indicated that carriers of LPL heterozygous mutations or deletions may exhibit normal plasma lipid levels or develop familial chylomicronemia syndrome
Outside the liver, some enzymes in the urea cycle have strong crosstalk with other metabolic pathways to rewire urea cycle intermediates to support the survival and proliferation of tumor cells (Keshet et al., 2018
The point is not to use those doses but to illustrate the wide safety margin
In those cases, a psychiatrist can help figure out whether the cause is the drug itself or something else
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