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In September 1977, the Annals of Internal Medicine published articles about patients who suffered liver damage after taking acetaminophen for an extended period of time at or slightly above therapeutic doses, underscoring what the Lancet had said about the drugs narrow margin for error

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Nevertheless, the high-resolution data we provide for both GSH and CP17 binding inform the pharmacophore definition and optimisation of small molecules to bind more strongly at the GSH pocket than GSH or CP17