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By downregulating NF-kB signaling, KPV reduces pro-inflammatory cytokine secretion without the immune suppression associated with corticosteroids or other pharmaceutical anti-inflammatories
The benzyl alcohol component permits multi-dose use over a typical 28-day window
TRIUMPH-1 (28.3%, 80 weeks, N=2,339) and TRIUMPH-4 (28.7%, 68 weeks, N=445) produced nearly identical efficacy results despite different populations and durations
EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) was the first major trial published evaluating SGLT2-i use for reduction of MACE in patients with type 2 diabetes and known CVD on empagliflozin
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