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The most commonly reported side effects for both agents are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

Because they stimulate insulin release in a glucose-dependent manner, the effect naturally diminishes as blood sugar drops toward normal levels

In research environments, melanocortin pathways may be studied in relation to signalling models, pigmentation-associated pathways, receptor response and wider peptide pathway comparisons

One study shows that raising glutathione levels prolongs the patients pain-free walking distance, and improves local blood circulation