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The search was limited to outcome trials evaluating the efficacy of DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors on cardiovascular, heart failure or renal outcomes in adult patients with or without type 2 diabetes
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The advancement occurred with the creation of exenatide, originating from exendin-4, a substance found in Gila monster saliva that inherently resisted DPP-4 destruction (Furman 2012)
However, this suppression isnt universal, and some individuals may experience rebound hunger when the medication wears off, leading to overeating
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