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It is also worth investigating pathways that GLP-1RAs may affect in the pathophysiology of lymphedema as it is unclear whether their potential effects are related to weight loss alone or interactions with known inflammatory pathways of lymphedema

Given that establishing biological efficacy is the primary objective of the trial, according to the pre-specified estimand, all participants who achieve at least 80% study medication compliance and provide a 180-day blood sample will be included in the primary efficacy analysis

The Problem With the Miracle Mindset isnt the medication

Reduced evening appetite means less nighttime eating, which can improve sleep quality