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This strategy not only overcomes the dual challenges of intracellular proteins being undruggable and inefficient brain delivery, providing a precise intervention pathway for ALS, but its modular design can also be adapted for the treatment of other RNA-binding protein-related neurodegenerative diseases by replacing the Oligo-PROTAC sequence to target tau protein and so on, establishing a new paradigm for the synergistic translation of nucleic acid-based PROTACs and brain-targeted carriers [100]
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As fatty plaques continue to grow, they can narrow the arteries and limit blood supply to your vital organs
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