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Canagliflozin significantly inhibits inflammatory factor expression, including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, exerting cardioprotective effects by regulating inflammation and ferroptosis through the AMP-activated protein kinase (AMPK) pathway (83)
Dingzhen pills, a traditional herbal formulation, inhibit the cyclic GMP-AMP synthase/stimulator of interferon genes pathway to protect dopaminergic neurons (128)
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diabetic retinopathy complications, particularly in patients with pre-existing retinopathy
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