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The appearance of a pustular/papular rash associated with high levels of Vitamin B12 is well described in the medical literature even though the exact mechanism appears to be unknown
PMID: 34469539
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However, metabolic tracing of 13 C-heptanoate indicates that propionyl-CoA predominantly produces glutamine, which indicates that astrocytic metabolism is responsible for the majority of this anaplerotic pathway (Marin-Valencia et al., 2013)
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