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The clinical significance of this interaction has not been formally studied for phentermine specifically, but it is a known consideration with all oral medications taken alongside GLP-1 receptor agonists
Here a double-blinded, randomized (1:1), placebo-controlled trial using semaglutide 2.4 mg weekly (BARI-STEP) recruited adult participants at least 1 year after gastric bypass or sleeve gastrectomy with a suboptimal clinical response, defined as less than 20% weight loss from surgery
Neither semaglutide nor orlistat has a strict upper limit for how long it can be used
First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design
