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Ali explained that the lack of official approvals in this case may be less than they seem
Among the most recognized causes of secondary failure to anti-TNF- therapy is the formation of ADAs [137]
Song, M., Fung, T
It illustrates how pre-existing resistant subclones (e.g., with RRM2 amplification or dCK methylation) are selectively enriched by treatment, while sensitive clones (with high hENT1/dCK expression) are suppressed
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