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It has been reported that the dysbiosis of the gut microbiota contributed to the occurrence of GLP-1 resistance in T2D mice
The peptides administration has been linked to the release of serotonin in brain regions associated with mood and motor control, suggesting a bidirectional communication pathway between the gut and the brain
et al., Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA, The Lancet, 2023
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