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Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21

A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets

Nicholas J Lowe, Michael Gifford, Emil Tanghetti, Yves P Poulin, Mitchel Goldman, Yardy Tse, Paul Yamauchi, Helene Rosenzweig & Sewon Kang (2004) Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, doubleblind, randomized, parallelgroup study, Journal of Cosmetic and Laser Therapy, 6:2, 79-85, DOI: 10.1080/14764170410032406 16