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10.1016/j.devcel.2024.06.018 69 LeJ.KonN.LiT.WangS.-J.SuT.HibshooshH.et al (2015)
Lancet Public Health 2 , e277e285 (2017)
Clinical trials of SGLT2 inhibitors, including EMPA-REG, DAPA-HF, and DELIVER, showed these agents are associated with a significant decrease in heart failure hospitalizations and cardiovascular mortality in this population.16,17 Mani et al further reviewed the literature, confirming the exceptional impact SGLT2 inhibitors have on patients with heart failure
Shank2 knockout mice (e67 KO) exhibit decreased expression levels of Gabra2 and GABA receptor-mediated inhibitory signaling, which can be reversed by treatment with allosteric modulators of GABA-ARs (99, 100)
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