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In this case, the patients levothyroxine dosage was not adjusted to reflect his new, lower body weight, tipping the balance and sending him into a thyroid crisis
Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy
Key Challenges for Oral Tirzepatide: Stomach Acid: The highly acidic environment can neutralize the peptide
Nizari et al., 2021
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