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Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (55, 56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (5557)
The effect is consistent enough that BPC-157's discoverers named it "Body Protection Compound" specifically for this property
Fatty acid synthase (FASN) catalyzes de novo lipogenesis to generate the palmitic acid essential for this modification [17, 198, 199]
It is worth mentioning that Beta GSTs (GSTBs) and GSTOs as well as chloride intracellular channel proteins (CLICs), which belong to Cys-GSTs, are not found in plants
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