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Nef promotes neuropathology by upregulating CCL2 in microglia and enhancing IL-6 and IL-8 production in astrocytes [137,138,139], while also activating NADPH oxidase in phagocytes, thereby exacerbating neuroinflammation, myelin damage, and neuronal injury [134, 140]
LC separation, which followed the previously reported procedure 28 , was performed using a normal-phase (hydrophilic interaction chromatography, HILIC) column (ZIC-pHILIC
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In UK clinical practice, Water for Injections BP is the standard diluent for injectables
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