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These microinjuries cause miniature cell deaths -apoptosis in which targeted cells in the superficial dermis shrink and break apart
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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis
Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH
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