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Acting on two complementary points of the same axis, the two compounds are studied together for a larger, cleaner GH pulse than either produces alone with Ipamorelin chosen specifically because it raises GH with minimal spillover onto cortisol (the stress hormone) or prolactin
A recent meta-analysis including 6 trials and 4744 participants indicated that semaglutide reduced DBP by 2.5 mmHg in obese patients without DM [39]
The main risks are skin irritation with high concentrations and the contamination concerns associated with poorly sourced or improperly prepared formulations
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