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This broad tissue distribution explains why GLP-1 RAs exert effects on multiple organ systems simultaneously, a property that makes them particularly suited to address the complex pathophysiology of NASH, which involves dysregulation of glucose and lipid metabolism, insulin resistance, inflammation, and fibrosis
Toxicol Sci 49:156164 Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM et al (2009) Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
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