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While genetic deletion of TREM2 in murine sepsis models restored FAO and improved survival 58 , translation remains challenging, as a first-in-human trial of a TREM2 monoclonal antibody (NCT06877533) was recently terminated
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In a Phase 1 clinical trial, AMG133 demonstrated significant dose-dependent weight loss effects, achieving up to a 14.5% reduction in body weight compared to a 1.5% reduction for the placebo group on day 85
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