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SGLT2 inhibitors may improve metabolic profiles in selected non-pregnant patients, but any such use must remain strictly outside pregnancy, under reliable contraception, and with guideline-consistent discontinuation before conception attempts because of urogenital adverse effects and contraindications during pregnancy (155, 156)
However, lack of long-term adherence to lifestyle modifications and adverse side effects, poor bioavailability, rapid clearance, and instability of many approved medicines make obesity and diabetes management challenging
Diabetes, Obesity & Metabolism, 23 ,
While the laxative effects of magnesium are typically seen at doses of around 400 milligrams, Hamilton recommends starting lower, around 200 milligrams, to reduce the risk of diarrhea
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