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Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]
Published research (Stoeva MK et al., Gut Microbes, 2021) documents its butyrate-producing function
Reviews note the need for larger animal studies and more detailed mechanistic investigations [11]
No safety data exists for this population
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