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Roxadustat (FG-4592), an inhibitor of prolyl hydroxylase of hypoxia-inducible factor (HIF), mitigates folic acid-induced kidney fibrosis via the Akt/GSK-3/Nrf2 pathway [193]
Dermal collagen was quantified by confocal microscopy, and all other skin parameters were graded visually by experts
More recently, specific gene signatures (BTG3, EHF, EZH2, TACC3, TXN) and senescence-related long non-coding RNAs have refined stratification capabilities [37]
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