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The math is clean and predictable because the 5mg/ml concentration divides evenly into standard insulin syringe markings
GLP-1 binds to receptors of pancreatic beta cells that increase insulin sensitivitywhich can increase glucose uptake and lower blood sugar levels
Early Attempts: The Formulation Era (2000-2015) The earliest attempts to develop oral GLP-1 therapy focused on formulation strategies to protect peptides from gastrointestinal degradation and enhance their absorption
By the 1940s glucagon was being widely used for this purpose in Europe and North America (Unger)
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