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Symptoms and Presentation Symptoms vary widely and can occur without anaemia or macrocytosis: Fatigue, weakness, shortness of breath
Megaloblastic anaemiacharacterised by abnormally large, immature red blood cellsdevelops when B12 deficiency impairs DNA synthesis
Some peptides (like insulin) are extremely well studied and have known benefits in specific settings (like diabetes)
This means intrinsic factor, as well as other factors required for B 12 absorption, are not available
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