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The UK Medicines and Healthcare products Regulatory Agency issued safety guidance in 2024 requiring healthcare professionals to be aware of aspiration risk whilst emphasising individualised assessment [45]

Early clinical trial results, presented at addiction medicine conferences in 2024 and 2025, have reported that participants on semaglutide experienced fewer heavy drinking days, lower craving scores on validated assessment tools, and in some cohorts spontaneous reductions in other substance use that wasnt being directly targeted