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13 NONCLINICAL TOXICOLOGY NONCLINICAL TOXICOLOGY SECTION 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY SECTION In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day (2-, 8-, and 22-fold the maximum recommended human dose [MRHD] of 2.4 mg/week, based on AUC) were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (0.6-, 2-, and 5-fold MRHD) were administered to the females
The gap between those two figures is where most unpleasant surprises live
Grey, white, clay-colored, or floating stools can visually indicate some problems with fat digestion
Eligibility criteria for non-diabetic tirzepatide use typically include a BMI of 30 kg/m or higher, or a BMI of 27 kg/m or higher with at least one weight-related health condition (such as hypertension, sleep apnea, or cardiovascular disease)
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