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Importantly, payer reimbursement restrictions are probably in place because previous cost-effectiveness analyses of these medications have considered at least some measure of their glycaemic benefits [13, 14], while whether SGLT2is and GLP-1 RAs are cost-effective solely on the basis of their benefits on cardiovascular and kidney disease has never been studied as far as we are aware
The PubMed search strategy used was: ((Insulin Resistance[MeSH Terms] OR Metabolic Syndrome[MeSH Terms] OR Glucose Intolerance[MeSH Terms] OR Prediabetic State[MeSH Terms] OR Insulin Resistance[Title/Abstract] OR Metabolic Syndrome[Title/Abstract] OR Glucose Intolerance[Title/Abstract] OR prediabetes[Title/Abstract]) AND (Akkermansia[Title/Abstract] OR Akkermansia muciniphila[Title/Abstract] OR a muciniphila[Title/Abstract] OR muciniphila[Title/Abstract])) AND ((ffrft[Filter]) AND (fft[Filter]) AND (english[Filter])) In addition to PubMed, Europe PMC was utilized to increase search sensitivity by identifying relevant full-text articles, preprints, and research outputs supported by European funding agencies, ensuring broader international coverage of the available evidence
Additionally, B12 is involved in energy metabolism, aiding in the conversion of food into energy, and has implications for mood regulation through its role in neurotransmitter synthesis
