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The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability
Once injected, B12 enters the bloodstream directly without requiring stomach acid, intrinsic factor (a protein necessary for B12 absorption), or healthy intestinal function
Others worry that patients won't understand what they're buying
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