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Dynamic light scattering (DLS) measurements demonstrated that NP4 had an average hydrodynamic diameter of 126 nm and a PDI of 0.16 (Fig
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Also, salvianolic acid B pretreatment induces Nrf2 and phase II enzymes by activating phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) pathways, thereby preventing acetaminophen-induced hepatotoxicity in mice (Lin et al., 2015)
If there has been long-standing damage, this triggering might overwhelm the system, temporarily worsening symptoms
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