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For systemic or injectable use, interaction data is nonexistent, and the risk assessment defaults to the broader concerns already discussed: unverified purity, uncontrolled dosing, and absent human trials
doi:10.1016/j.numecd.2017.06.014 Djiogue S, Nwabo Kamdje AH, Vecchio L, et al
Genes Immun (2009) 10:114
However, an intrinsic limitation of tagging is that the native function of the protein may be compromised or even abolished by the presence of the tag
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