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3 Metabolic outcomes of GLP-1RAs in PCOS: from evidence synthesis to Bayesian probability integration The interpretation of clinical evidence presented below follows the core tension between metabolic risk fertility window, as illustrated in Figure 1A: achieving metabolic optimization within a finite reproductive window while strictly adhering to discontinuation and washout protocols to mitigate periconception exposure risks

The absence of published full-text human clinical trials remains the most significant limitation in the evidence base

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