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The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice
In isolated rat aorta preparations, the peptide produced concentration-dependent vasodilation that was endothelium-dependent and abolished by L-NAME, and co-immunoprecipitation work traced the response to phosphorylation of Src, caveolin-1, and endothelial nitric oxide synthase, with reduced binding between caveolin-1 and eNOS [1]
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This cloudiness comes from peptide aggregation, and it means a significant portion of the active ingredient is no longer functional
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