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Discomfort On the downside, injections can be uncomfortable and a barrier for some patients

Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

Ensuring that -CC-mediated adaptations are both effective and ecologically sustainable will require multi-environment validation and long-term systems-level assessment

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