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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness
Mansour G, Abdelrazik H, Sharma RK, Radwan E, Falcone T, Agarwal A
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