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This imbalance of antioxidants in TED patients is due to the growth of orbital fibroblasts, synthesis of autoantibodies, degradation of preadipocytes to adipocytes, and secretion of endogenous cytokines (TNF, IL1-, and IFN), which consequently leads to fibro-adipose tissue development and inflammation of the extraocular muscle
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The canonical Wnt pathway, which includes low density lipoprotein receptor-related protein 5/6, -catenin, GSK-3, and T cell factor (42), promotes osteoblast differentiation and maturation (43)
Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies
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