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The Khavinson primate studies are most relevant here: Epitalon increased nighttime melatonin in old monkeys while having no effect on young ones

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Vitamin C is the best-studied and understood antioxidant: a substance that readily donates electrons to neutralize potentially damaging oxidative free radicals. As our cells use oxygen to make energy, they create oxygen free radicals, which must be tightly controlled or they can destroy DNA, proteins, and other key cell components

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