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On one hand, ROS-mediated damage to the cystine-glutamate antiporter SLC7A11expressed on RMECs, RPE cells, and Mller cellsimpairs cystine-cysteine biotransformation, disrupts the GSH- GPX4 antioxidant axis, and thereby triggers ferroptosis in these cell populations
This study further demonstrated that exendin-4 treatment additionally reduced the presence of key inflammatory molecules, including TNF-alpha, interleukin 1 beta (IL-1beta), and IL-6, in mice livers [46], providing evidence for potential GLP-1 treatment for inflammation related to steatohepatitis
the actual reta+cagri combination has zero published trial data
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